Difference between revisions of "LON protease"

From Aging Chart
Jump to: navigation, search
(Autoloading by CXLParser)
(Autoloading by CXLParser)
 
Line 42: Line 42:
 
height=0.28,
 
height=0.28,
 
fontsize=12,
 
fontsize=12,
shape=rectangle, color="#ffff99ff"];
+
shape=rectangle, color="#ffff00ff"];
 
"1HXLT12QR-12ZXD3X-5MW" [id="1HXLT12QR-12ZXD3X-5MW",
 
"1HXLT12QR-12ZXD3X-5MW" [id="1HXLT12QR-12ZXD3X-5MW",
 
URL="#1HXLT12QR-12ZXD3X-5MW",
 
URL="#1HXLT12QR-12ZXD3X-5MW",
Line 50: Line 50:
 
height=0.32,
 
height=0.32,
 
fontsize=12,
 
fontsize=12,
shape=rectangle, color="#ffff99ff"];
+
shape=rectangle, color="#ffff00ff"];
 
"1HXLSWWXW-15JJC98-5G6" [id="1HXLSWWXW-15JJC98-5G6",
 
"1HXLSWWXW-15JJC98-5G6" [id="1HXLSWWXW-15JJC98-5G6",
 
URL="#1HXLSWWXW-15JJC98-5G6",
 
URL="#1HXLSWWXW-15JJC98-5G6",
Line 96: Line 96:
 
(.//.)<html><!--Pop-up for: Oxidized mitochondrial matrix proteins  (e.g., hydrophobic oxidized aconitase) !Pop-up-->
 
(.//.)<html><!--Pop-up for: Oxidized mitochondrial matrix proteins  (e.g., hydrophobic oxidized aconitase) !Pop-up-->
 
<div class="1HXLSCWRZ-1VJQT7L-4R6" style="display:none;">
 
<div class="1HXLSCWRZ-1VJQT7L-4R6" style="display:none;">
 +
  
  
Line 107: Line 108:
 
</div>(...)<!--Pop-up for: Mitochondrial LON protease !Pop-up-->
 
</div>(...)<!--Pop-up for: Mitochondrial LON protease !Pop-up-->
 
<div class="1HXLSCKY6-XVXWJB-4Q8" style="display:none;">
 
<div class="1HXLSCKY6-XVXWJB-4Q8" style="display:none;">
 +
  
  
Line 118: Line 120:
 
</div>(...)<!--Pop-up for: Chaperon in assembly  Of electron-transport chain !Pop-up-->
 
</div>(...)<!--Pop-up for: Chaperon in assembly  Of electron-transport chain !Pop-up-->
 
<div class="1HXLSZC22-WCDMQL-5HH" style="display:none;">
 
<div class="1HXLSZC22-WCDMQL-5HH" style="display:none;">
 +
  
  
Line 129: Line 132:
 
</div>(...)<!--Pop-up for: ATP !Pop-up-->
 
</div>(...)<!--Pop-up for: ATP !Pop-up-->
 
<div class="1HXLSP5KT-253W4HH-55W" style="display:none;">
 
<div class="1HXLSP5KT-253W4HH-55W" style="display:none;">
 +
  
  
Line 140: Line 144:
 
</div>(...)<!--Pop-up for: Destabilization of the mtDNA !Pop-up-->
 
</div>(...)<!--Pop-up for: Destabilization of the mtDNA !Pop-up-->
 
<div class="1HXLT2K79-Y42B5D-5RX" style="display:none;">
 
<div class="1HXLT2K79-Y42B5D-5RX" style="display:none;">
 +
  
  
Line 151: Line 156:
 
</div>(...)<!--Pop-up for: Binding of mtDNA !Pop-up-->
 
</div>(...)<!--Pop-up for: Binding of mtDNA !Pop-up-->
 
<div class="1HXLT12QR-12ZXD3X-5MW" style="display:none;">
 
<div class="1HXLT12QR-12ZXD3X-5MW" style="display:none;">
 +
  
  
Line 162: Line 168:
 
</div>(...)<!--Pop-up for: Oxidized aconitase !Pop-up-->
 
</div>(...)<!--Pop-up for: Oxidized aconitase !Pop-up-->
 
<div class="1HXLSWWXW-15JJC98-5G6" style="display:none;">
 
<div class="1HXLSWWXW-15JJC98-5G6" style="display:none;">
 +
  
  
Line 173: Line 180:
 
</div>(...)<!--Pop-up for: Formation of oxidized  Proteins aggregates  !Pop-up-->
 
</div>(...)<!--Pop-up for: Formation of oxidized  Proteins aggregates  !Pop-up-->
 
<div class="1HXLSGHZ3-12DPQ2X-4WX" style="display:none;">
 
<div class="1HXLSGHZ3-12DPQ2X-4WX" style="display:none;">
 +
  
  
Line 184: Line 192:
 
</div>(...)<!--Pop-up for: Toxic aggregates !Pop-up-->
 
</div>(...)<!--Pop-up for: Toxic aggregates !Pop-up-->
 
<div class="1HXLT36PV-1RHH1DW-5T9" style="display:none;">
 
<div class="1HXLT36PV-1RHH1DW-5T9" style="display:none;">
 +
  
  
Line 195: Line 204:
 
</div>(...)<!--Pop-up for: Reducing of  Expression and activity  Of LON protease  With age !Pop-up-->
 
</div>(...)<!--Pop-up for: Reducing of  Expression and activity  Of LON protease  With age !Pop-up-->
 
<div class="1HXLSW2CN-S8HXNF-5DB" style="display:none;">
 
<div class="1HXLSW2CN-S8HXNF-5DB" style="display:none;">
 +
  
  

Latest revision as of 10:25, 2 August 2015

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

LON protease

Mitochondrial aconitase is sensitive to oxidative inactivation and can aggregate and accumulate in many age-related disorders. Lon protease, an ATP-stimulated mitochondrial matrix protein, selectively recognizes and degrades the oxidized, hydrophobic form of aconitase after mild oxidative modification. The ATP-stimulated Lon protease may be an essential defence against the stress of life in an oxygen environment. By recognizing minor oxidative changes to protein structure and rapidly degrading the mildly modified protein, Lon protease may prevent extensive oxidation, aggregation and accumulation of aconitase, which could otherwise compromise mitochondrial function and cellular viability. Aconitase is probably only one of many mitochondrial matrix proteins that are preferentially degraded by Lon protease after oxidative modification.

The ATP-dependent Lon protease belongs to a unique group of proteases that bind DNA.  human Lon binds specifically to a single-stranded GT-rich DNA sequence overlapping the light strand promoter of human mitochondrial DNA (mtDNA). Conformational changes in the Lon holoenzyme induced by nucleotide and protein substrate modulate the binding affinity for single-stranded mtDNA and RNA in vivo. Co-immunoprecipitation experiments show that Lon interacts with mtDNA polymerase γ and the Twinkle helicase, which are components of mitochondrial nucleoids.