Difference between revisions of "GADD45 pathway"

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(Autoloading by CXLParser)
(Autoloading by CXLParser)
 
(5 intermediate revisions by the same user not shown)
Line 1: Line 1:
 
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Line 546: Line 544:
 
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Line 552: Line 550:
 
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Line 564: Line 562:
 
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Line 578: Line 576:
 
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Line 588: Line 586:
 
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"1NK007VGF-1GZ7QCT-1XK3" -> "1J4WPKGNN-29W5M0H-6VS" [color="#0000ffff"]
 
"1J4WR2YP6-L0T57T-8NH" -> "1J4WR4048-DCFBH6-8PN" [color="#008000ff"]
 
"1J4WR2YP6-L0T57T-8NH" -> "1J4WR4048-DCFBH6-8PN" [color="#008000ff"]
"1J4WS1PPW-1100NFG-B7M" -> "1NB5JYX09-14KHWXJ-1R35" [color="#000000ff"]
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"1J4WS1PPW-1100NFG-B7M" -> "1NB5JYX09-14KHWXJ-1R35" [arrowhead=none, color="#000000ff"]
 
"1NK00GS0N-19K1V2K-1XP8" -> "1J4WR4048-DCFBH6-8PN" [color="#008000ff"]
 
"1NK00GS0N-19K1V2K-1XP8" -> "1J4WR4048-DCFBH6-8PN" [color="#008000ff"]
 
"1J4WRWDRQ-1NY06KT-B1Z" -> "1J4WPKGNN-29W5M0H-6VS" [color="#008000ff"]
 
"1J4WRWDRQ-1NY06KT-B1Z" -> "1J4WPKGNN-29W5M0H-6VS" [color="#008000ff"]
 
"1J4WQYPPZ-28BCRN3-8FS" -> "1J4WQZVQX-1HJG0JH-8H0" [color="#008000ff"]
 
"1J4WQYPPZ-28BCRN3-8FS" -> "1J4WQZVQX-1HJG0JH-8H0" [color="#008000ff"]
"1J4WPLS97-JVQJRM-6Y0" -> "1NB5D7XFB-1RVQM04-1PHQ" [color="#000000ff"]
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"1J4WPLS97-JVQJRM-6Y0" -> "1NB5D7XFB-1RVQM04-1PHQ" [arrowhead=none, color="#000000ff"]
 
"1NB5D7PK2-28VLNWS-1PHL" -> "1J4WQSMFH-1BZ66T9-88V" [color="#008000ff"]
 
"1NB5D7PK2-28VLNWS-1PHL" -> "1J4WQSMFH-1BZ66T9-88V" [color="#008000ff"]
 
"1NB5D8B5N-Z1VV2S-1PHZ" -> "1J4WQSMFH-1BZ66T9-88V" [color="#008000ff"]
 
"1NB5D8B5N-Z1VV2S-1PHZ" -> "1J4WQSMFH-1BZ66T9-88V" [color="#008000ff"]
Line 600: Line 598:
 
"1J4WPRSTT-SHXM8L-70B" -> "1NK007VGF-1GZ7QCT-1XK3" [color="#008000ff"]
 
"1J4WPRSTT-SHXM8L-70B" -> "1NK007VGF-1GZ7QCT-1XK3" [color="#008000ff"]
 
"1NK00GK8Y-Z96MRP-1XNZ" -> "1J4WR4048-DCFBH6-8PN" [color="#008000ff"]
 
"1NK00GK8Y-Z96MRP-1XNZ" -> "1J4WR4048-DCFBH6-8PN" [color="#008000ff"]
"1J4WPQMSC-193N5V2-6ZW" -> "1NKRC491D-1S67JNN-2TL" [color="#000000ff"]
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"1J4WPQMSC-193N5V2-6ZW" -> "1NKRC491D-1S67JNN-2TL" [arrowhead=none, color="#000000ff"]
 
"1J4WQ6ZSX-TK6RFP-7MX" -> "1J4WSW503-N577FM-CYQ" [color="#008000ff"]
 
"1J4WQ6ZSX-TK6RFP-7MX" -> "1J4WSW503-N577FM-CYQ" [color="#008000ff"]
 
"1J4WPS05W-953WQ6-70L" -> "1J4WPYLCB-13WN7PC-76H" [color="#008000ff"]
 
"1J4WPS05W-953WQ6-70L" -> "1J4WPYLCB-13WN7PC-76H" [color="#008000ff"]
Line 613: Line 611:
 
"1NK00J53K-23N2F81-1XRC" -> "1J4WR4048-DCFBH6-8PN" [color="#008000ff"]
 
"1NK00J53K-23N2F81-1XRC" -> "1J4WR4048-DCFBH6-8PN" [color="#008000ff"]
 
"1NKRC491D-1S67JNN-2TL" -> "1J4WPKGNN-29W5M0H-6VS" [color="#008000ff"]
 
"1NKRC491D-1S67JNN-2TL" -> "1J4WPKGNN-29W5M0H-6VS" [color="#008000ff"]
"1J4WPLS97-JVQJRM-6Y0" -> "1NB5D7PK2-28VLNWS-1PHL" [color="#000000ff"]
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"1J4WPLS97-JVQJRM-6Y0" -> "1NB5D7PK2-28VLNWS-1PHL" [arrowhead=none, color="#000000ff"]
 
"1NK00HQ7W-120G3YL-1XQX" -> "1J4WR4048-DCFBH6-8PN" [color="#008000ff"]
 
"1NK00HQ7W-120G3YL-1XQX" -> "1J4WR4048-DCFBH6-8PN" [color="#008000ff"]
 
"1J4WR7CRQ-1K5R75T-8WQ" -> "1J4WPKGNN-29W5M0H-6VS" [color="#008000ff"]
 
"1J4WR7CRQ-1K5R75T-8WQ" -> "1J4WPKGNN-29W5M0H-6VS" [color="#008000ff"]
 
"1NB5DK1HP-CKF4LS-1PRX" -> "1J4WPV9NL-1PXSD8V-72Y" [color="#008000ff"]
 
"1NB5DK1HP-CKF4LS-1PRX" -> "1J4WPV9NL-1PXSD8V-72Y" [color="#008000ff"]
 
"1J4WPRSTT-SHXM8L-70B" -> "1NKRC4HKM-17CVDRV-2TW" [color="#0000ffff"]
 
"1J4WPRSTT-SHXM8L-70B" -> "1NKRC4HKM-17CVDRV-2TW" [color="#0000ffff"]
"1J4WPKGNN-29W5M0H-6VS" -> "1J4WQJMDG-151RWXJ-82Q" [color="#ff0000ff"]
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"1J4WPKGNN-29W5M0H-6VS" -> "1J4WQJMDG-151RWXJ-82Q" [arrowhead=tee, color="#ff0000ff"]
"1J4WSNN7L-7XMJ5L-C9B" -> "1J4WR8X0Y-1X31K6X-922" [color="#ff0000ff"]
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"1J4WSNN7L-7XMJ5L-C9B" -> "1J4WR8X0Y-1X31K6X-922" [arrowhead=tee, color="#ff0000ff"]
 
"1J4WPKGNN-29W5M0H-6VS" -> "1NK00HD9H-28WFHXW-1XQ7" [color="#008000ff"]
 
"1J4WPKGNN-29W5M0H-6VS" -> "1NK00HD9H-28WFHXW-1XQ7" [color="#008000ff"]
 
"1J4WPS6T0-M4133K-70W" -> "1J4WQZVQX-1HJG0JH-8H0" [color="#008000ff"]
 
"1J4WPS6T0-M4133K-70W" -> "1J4WQZVQX-1HJG0JH-8H0" [color="#008000ff"]
"1J4WPKGNN-29W5M0H-6VS" -> "1J4WRP36Q-2DN9LM2-9G4" [color="#ff0000ff"]
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"1J4WPKGNN-29W5M0H-6VS" -> "1J4WRP36Q-2DN9LM2-9G4" [arrowhead=tee, color="#ff0000ff"]
"1J4WQJMDG-151RWXJ-82Q" -> "1J4WQ4VRJ-XT7ZDD-7JV" [color="#ff0000ff"]
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"1J4WQJMDG-151RWXJ-82Q" -> "1J4WQ4VRJ-XT7ZDD-7JV" [arrowhead=tee, color="#ff0000ff"]
 
"1J4WPKGNN-29W5M0H-6VS" -> "1NK00HQ7W-120G3YL-1XQX" [color="#008000ff"]
 
"1J4WPKGNN-29W5M0H-6VS" -> "1NK00HQ7W-120G3YL-1XQX" [color="#008000ff"]
 
"1J4WR8X0Y-1X31K6X-922" -> "1J4WR9DH8-9DZB5B-944" [color="#0000ffff"]
 
"1J4WR8X0Y-1X31K6X-922" -> "1J4WR9DH8-9DZB5B-944" [color="#0000ffff"]
Line 629: Line 627:
 
"1NB5JYX09-14KHWXJ-1R35" -> "1J4WPKGNN-29W5M0H-6VS" [color="#008000ff"]
 
"1NB5JYX09-14KHWXJ-1R35" -> "1J4WPKGNN-29W5M0H-6VS" [color="#008000ff"]
 
"1NB5JZ7NY-1WJ1PDQ-1R3F" -> "1J4WPKGNN-29W5M0H-6VS" [color="#008000ff"]
 
"1NB5JZ7NY-1WJ1PDQ-1R3F" -> "1J4WPKGNN-29W5M0H-6VS" [color="#008000ff"]
"1J4WPQMSC-193N5V2-6ZW" -> "1NKRC4HKM-17CVDRV-2TW" [color="#000000ff"]
+
"1J4WPQMSC-193N5V2-6ZW" -> "1NKRC4HKM-17CVDRV-2TW" [arrowhead=none, color="#000000ff"]
 
"1J4WPRSTT-SHXM8L-70B" -> "1J4WPYLCB-13WN7PC-76H" [color="#008000ff"]
 
"1J4WPRSTT-SHXM8L-70B" -> "1J4WPYLCB-13WN7PC-76H" [color="#008000ff"]
 
"1J4WR8X0Y-1X31K6X-922" -> "1J4WPQMSC-193N5V2-6ZW" [color="#0000ffff"]
 
"1J4WR8X0Y-1X31K6X-922" -> "1J4WPQMSC-193N5V2-6ZW" [color="#0000ffff"]
Line 638: Line 636:
 
"1J4WPSQ9C-WWBLV4-71G" -> "1J4WQ99F5-1MQYTXP-7SW" [color="#008000ff"]
 
"1J4WPSQ9C-WWBLV4-71G" -> "1J4WQ99F5-1MQYTXP-7SW" [color="#008000ff"]
 
"1J4WPRSTT-SHXM8L-70B" -> "1J4WQ2DQP-XBGSCT-7FM" [color="#008000ff"]
 
"1J4WPRSTT-SHXM8L-70B" -> "1J4WQ2DQP-XBGSCT-7FM" [color="#008000ff"]
"1NB5DJ166-22PDQ62-1PRD" -> "1J4WQ6C51-1GW4594-7LP" [color="#ff0000ff"]
+
"1NB5DJ166-22PDQ62-1PRD" -> "1J4WQ6C51-1GW4594-7LP" [arrowhead=tee, color="#ff0000ff"]
 
"1J4WSW503-N577FM-CYQ" -> "1J4WPKGNN-29W5M0H-6VS" [color="#0000ffff"]
 
"1J4WSW503-N577FM-CYQ" -> "1J4WPKGNN-29W5M0H-6VS" [color="#0000ffff"]
"1J4WPV9NL-1PXSD8V-72Y" -> "1J4WQC0YG-6GFQCB-7YG" [color="#ff0000ff"]
+
"1J4WPV9NL-1PXSD8V-72Y" -> "1J4WQC0YG-6GFQCB-7YG" [arrowhead=tee, color="#ff0000ff"]
 
"1J4WPRSTT-SHXM8L-70B" -> "1J4WPSQ9C-WWBLV4-71G" [color="#008000ff"]
 
"1J4WPRSTT-SHXM8L-70B" -> "1J4WPSQ9C-WWBLV4-71G" [color="#008000ff"]
"1J4WQSMFH-1BZ66T9-88V" -> "1J4WPKGNN-29W5M0H-6VS" [color="#ff0000ff"]
+
"1J4WQSMFH-1BZ66T9-88V" -> "1J4WPKGNN-29W5M0H-6VS" [arrowhead=tee, color="#ff0000ff"]
"1J4WS1PPW-1100NFG-B7M" -> "1NB5JY6MD-1JT7BKF-1R2R" [color="#000000ff"]
+
"1J4WS1PPW-1100NFG-B7M" -> "1NB5JY6MD-1JT7BKF-1R2R" [arrowhead=none, color="#000000ff"]
 
} </graphviz>(.//.)
 
} </graphviz>(.//.)
 
<!-- Categories list. You can add something if need. -->
 
<!-- Categories list. You can add something if need. -->
 
(.//.)<html><!--Pop-up for: Inflammation !Pop-up-->
 
(.//.)<html><!--Pop-up for: Inflammation !Pop-up-->
 
<div class="1J4WR8X0Y-1X31K6X-922" style="display:none;">
 
<div class="1J4WR8X0Y-1X31K6X-922" style="display:none;">
 +
 +
 +
 +
 +
 +
  
  
 
<h3>Inflammation</h3>
 
<h3>Inflammation</h3>
<div class="links"> </div>
+
<div class="links"><a href="http://www.ncbi.nlm.nih.gov/pubmed/15797874">PMID: 15797874</a><br /></div>
 
</div>(...)<!--Pop-up for: PCNA !Pop-up-->
 
</div>(...)<!--Pop-up for: PCNA !Pop-up-->
 
<div class="1J4WPS6T0-M4133K-70W" style="display:none;">
 
<div class="1J4WPS6T0-M4133K-70W" style="display:none;">
 +
 +
 +
 +
 +
 +
  
  
 
<h3>PCNA</h3>
 
<h3>PCNA</h3>
<div class="links"> </div>
+
<div class="links"><a href="http://www.ncbi.nlm.nih.gov/pubmed/10828065">PMID: 10828065</a><br /></div>
 
</div>(...)<!--Pop-up for: ERK 1/2 !Pop-up-->
 
</div>(...)<!--Pop-up for: ERK 1/2 !Pop-up-->
 
<div class="1J4WRRMQ6-9CY9CW-9MS" style="display:none;">
 
<div class="1J4WRRMQ6-9CY9CW-9MS" style="display:none;">
 +
 +
 +
 +
 +
 +
  
  
 
<h3>ERK 1/2</h3>
 
<h3>ERK 1/2</h3>
<div class="links"> </div>
+
<div class="links"><a href="http://www.ncbi.nlm.nih.gov/pubmed/14971655">PMID: 14971655</a><br /></div>
 
</div>(...)<!--Pop-up for: PPARγ2  !Pop-up-->
 
</div>(...)<!--Pop-up for: PPARγ2  !Pop-up-->
 
<div class="1NK00LD50-1CGDW7G-1XWX" style="display:none;">
 
<div class="1NK00LD50-1CGDW7G-1XWX" style="display:none;">
 +
 +
 +
 +
 +
 +
  
  
 
<h3>PPARγ2 </h3>
 
<h3>PPARγ2 </h3>
<div class="links"> </div>
+
<div class="links"><a href="http://www.ncbi.nlm.nih.gov/pubmed/10872826">PMID: 10872826</a><br /></div>
 
</div>(...)<!--Pop-up for: Cdc2/cyclinB1 !Pop-up-->
 
</div>(...)<!--Pop-up for: Cdc2/cyclinB1 !Pop-up-->
 
<div class="1J4WQJMDG-151RWXJ-82Q" style="display:none;">
 
<div class="1J4WQJMDG-151RWXJ-82Q" style="display:none;">
 +
 +
 +
 +
 +
 +
  
  
 
<h3>Cdc2/cyclinB1</h3>
 
<h3>Cdc2/cyclinB1</h3>
<div class="links"> </div>
+
<div class="links"><a href="http://www.ncbi.nlm.nih.gov/pubmed/12124778">PMID: 12124778</a><br /></div>
 
</div>(...)<!--Pop-up for: GCSF !Pop-up-->
 
</div>(...)<!--Pop-up for: GCSF !Pop-up-->
 
<div class="1NB5JYX09-14KHWXJ-1R35" style="display:none;">
 
<div class="1NB5JYX09-14KHWXJ-1R35" style="display:none;">
 +
 +
 +
 +
 +
 +
  
  
 
<h3>GCSF</h3>
 
<h3>GCSF</h3>
<div class="links"> </div>
+
<div class="links"><a href="http://www.ncbi.nlm.nih.gov/pubmed/10490824">PMID: 10490824</a><br /></div>
 
</div>(...)<!--Pop-up for: IL-12 !Pop-up-->
 
</div>(...)<!--Pop-up for: IL-12 !Pop-up-->
 
<div class="1NB5D82CW-QT4LXX-1PHV" style="display:none;">
 
<div class="1NB5D82CW-QT4LXX-1PHV" style="display:none;">
 +
 +
 +
 +
 +
 +
  
  
 
<h3>IL-12</h3>
 
<h3>IL-12</h3>
<div class="links"> </div>
+
<div class="links"><a href="http://www.ncbi.nlm.nih.gov/pubmed/18501677">PMID: 18501677</a><br /></div>
 
</div>(...)<!--Pop-up for: TNF-α  !Pop-up-->
 
</div>(...)<!--Pop-up for: TNF-α  !Pop-up-->
 
<div class="1NKRC4HKM-17CVDRV-2TW" style="display:none;">
 
<div class="1NKRC4HKM-17CVDRV-2TW" style="display:none;">
 +
 +
 +
 +
 +
 +
  
  
 
<h3>TNF-α </h3>
 
<h3>TNF-α </h3>
<div class="links"> </div>
+
<div class="links"><a href="http://www.ncbi.nlm.nih.gov/pubmed/8139540">PMID: 8139540</a><br /></div>
 
</div>(...)<!--Pop-up for: BRCA1 !Pop-up-->
 
</div>(...)<!--Pop-up for: BRCA1 !Pop-up-->
 
<div class="1J4WPSVQG-11QY2G7-71Q" style="display:none;">
 
<div class="1J4WPSVQG-11QY2G7-71Q" style="display:none;">
 +
 +
 +
 +
 +
 +
  
  
 
<h3>BRCA1</h3>
 
<h3>BRCA1</h3>
<div class="links"> </div>
+
<div class="links"><a href="http://www.ncbi.nlm.nih.gov/pubmed/11777930">PMID: 11777930</a><br /><a href="http://www.ncbi.nlm.nih.gov/pubmed/15123655">PMID: 15123655</a><br /></div>
 
</div>(...)<!--Pop-up for: IL-6 !Pop-up-->
 
</div>(...)<!--Pop-up for: IL-6 !Pop-up-->
 
<div class="1NB5D7XFB-1RVQM04-1PHQ" style="display:none;">
 
<div class="1NB5D7XFB-1RVQM04-1PHQ" style="display:none;">
 +
 +
 +
 +
 +
 +
  
  
 
<h3>IL-6</h3>
 
<h3>IL-6</h3>
<div class="links"> </div>
+
<div class="links"><a href="http://www.ncbi.nlm.nih.gov/pubmed/11175814">PMID: 11175814</a><br /></div>
 
</div>(...)<!--Pop-up for: Apoptosis !Pop-up-->
 
</div>(...)<!--Pop-up for: Apoptosis !Pop-up-->
 
<div class="1J4WPYLCB-13WN7PC-76H" style="display:none;">
 
<div class="1J4WPYLCB-13WN7PC-76H" style="display:none;">
 +
 +
 +
 +
 +
 +
  
  
 
<h3>Apoptosis</h3>
 
<h3>Apoptosis</h3>
<div class="links"> </div>
+
<div class="links"><a href="http://www.ncbi.nlm.nih.gov/pubmed/12933797">PMID: 12933797</a><br /></div>
 
</div>(...)<!--Pop-up for: Expression of genes required for cell survival !Pop-up-->
 
</div>(...)<!--Pop-up for: Expression of genes required for cell survival !Pop-up-->
 
<div class="1J4WR4048-DCFBH6-8PN" style="display:none;">
 
<div class="1J4WR4048-DCFBH6-8PN" style="display:none;">
 +
 +
 +
 +
 +
 +
  
  
 
<h3>Expression of genes required for cell survival</h3>
 
<h3>Expression of genes required for cell survival</h3>
<div class="links"> </div>
+
<div class="links"><a href="http://www.ncbi.nlm.nih.gov/pubmed/15483317">PMID: 15483317</a><br /></div>
 
</div>(...)<!--Pop-up for: P53 !Pop-up-->
 
</div>(...)<!--Pop-up for: P53 !Pop-up-->
 
<div class="1NK007VGF-1GZ7QCT-1XK3" style="display:none;">
 
<div class="1NK007VGF-1GZ7QCT-1XK3" style="display:none;">
 +
 +
 +
 +
 +
 +
  
  
 
<h3>P53</h3>
 
<h3>P53</h3>
<div class="links"> </div>
+
<div class="links"><a href="http://www.ncbi.nlm.nih.gov/pubmed/10101800">PMID: 10101800</a><br /><a href="http://www.ncbi.nlm.nih.gov/pubmed/10749144">PMID: 10749144</a><br /></div>
 
</div>(...)<!--Pop-up for: Immunity !Pop-up-->
 
</div>(...)<!--Pop-up for: Immunity !Pop-up-->
 
<div class="1J4WSHRPH-283RH8X-C0Y" style="display:none;">
 
<div class="1J4WSHRPH-283RH8X-C0Y" style="display:none;">
 +
 +
 +
 +
 +
 +
  
  
 
<h3>Immunity</h3>
 
<h3>Immunity</h3>
<div class="links"> </div>
+
<div class="links"></div>
 
</div>(...)<!--Pop-up for: Oxidative  Stress !Pop-up-->
 
</div>(...)<!--Pop-up for: Oxidative  Stress !Pop-up-->
 
<div class="1NB5DK52J-SZNDV0-1PS1" style="display:none;">
 
<div class="1NB5DK52J-SZNDV0-1PS1" style="display:none;">
 +
 +
 +
 +
 +
 +
  
  
 
<h3>Oxidative  Stress</h3>
 
<h3>Oxidative  Stress</h3>
<div class="links"> </div>
+
<div class="links"><a href="http://www.ncbi.nlm.nih.gov/pubmed/1990262">PMID: 1990262</a><br /></div>
 
</div>(...)<!--Pop-up for: NF-kB !Pop-up-->
 
</div>(...)<!--Pop-up for: NF-kB !Pop-up-->
 
<div class="1J4WQSMFH-1BZ66T9-88V" style="display:none;">
 
<div class="1J4WQSMFH-1BZ66T9-88V" style="display:none;">
 +
 +
 +
 +
 +
 +
  
  
 
<h3>NF-kB</h3>
 
<h3>NF-kB</h3>
<div class="links"> </div>
+
<div class="links"><a href="http://www.ncbi.nlm.nih.gov/pubmed/15031557">PMID: 15031557</a><br /></div>
 
</div>(...)<!--Pop-up for: RXRα !Pop-up-->
 
</div>(...)<!--Pop-up for: RXRα !Pop-up-->
 
<div class="1NK00HQ7W-120G3YL-1XQX" style="display:none;">
 
<div class="1NK00HQ7W-120G3YL-1XQX" style="display:none;">
 +
 +
 +
 +
 +
 +
  
  
 
<h3>RXRα</h3>
 
<h3>RXRα</h3>
<div class="links"> </div>
+
<div class="links"><a href="http://www.ncbi.nlm.nih.gov/pubmed/10872826">PMID: 10872826</a><br /></div>
 
</div>(...)<!--Pop-up for: Complement system  Component C5b-9  !Pop-up-->
 
</div>(...)<!--Pop-up for: Complement system  Component C5b-9  !Pop-up-->
 
<div class="1J4WR9DH8-9DZB5B-944" style="display:none;">
 
<div class="1J4WR9DH8-9DZB5B-944" style="display:none;">
 +
 +
 +
 +
 +
 +
  
  
 
<h3>Complement system  Component C5b-9 </h3>
 
<h3>Complement system  Component C5b-9 </h3>
<div class="links"> </div>
+
<div class="links"><a href="http://www.ncbi.nlm.nih.gov/pubmed/12639994">PMID: 12639994</a><br /></div>
 
</div>(...)<!--Pop-up for: PPARα !Pop-up-->
 
</div>(...)<!--Pop-up for: PPARα !Pop-up-->
 
<div class="1NK00HD9H-28WFHXW-1XQ7" style="display:none;">
 
<div class="1NK00HD9H-28WFHXW-1XQ7" style="display:none;">
 +
 +
 +
 +
 +
 +
  
  
 
<h3>PPARα</h3>
 
<h3>PPARα</h3>
<div class="links"> </div>
+
<div class="links"><a href="http://www.ncbi.nlm.nih.gov/pubmed/10872826">PMID: 10872826</a><br /></div>
 
</div>(...)<!--Pop-up for: carcinogenesis !Pop-up-->
 
</div>(...)<!--Pop-up for: carcinogenesis !Pop-up-->
 
<div class="1J4WSJJW0-21HHCZ3-C1V" style="display:none;">
 
<div class="1J4WSJJW0-21HHCZ3-C1V" style="display:none;">
 +
 +
 +
 +
 +
 +
  
  
 
<h3>carcinogenesis</h3>
 
<h3>carcinogenesis</h3>
<div class="links"> </div>
+
<div class="links"><a href="http://www.ncbi.nlm.nih.gov/pubmed/16951155">PMID: 16951155</a><br /></div>
 
</div>(...)<!--Pop-up for: FOXO !Pop-up-->
 
</div>(...)<!--Pop-up for: FOXO !Pop-up-->
 
<div class="1J4WSW503-N577FM-CYQ" style="display:none;">
 
<div class="1J4WSW503-N577FM-CYQ" style="display:none;">
 +
 +
 +
 +
 +
 +
  
  
 
<h3>FOXO</h3>
 
<h3>FOXO</h3>
<div class="links"> </div>
+
<div class="links"><a href="http://www.ncbi.nlm.nih.gov/pubmed/12048180">PMID: 12048180</a><br /></div>
 
</div>(...)<!--Pop-up for: Oncogeniс  Stress !Pop-up-->
 
</div>(...)<!--Pop-up for: Oncogeniс  Stress !Pop-up-->
 
<div class="1NB5DJ166-22PDQ62-1PRD" style="display:none;">
 
<div class="1NB5DJ166-22PDQ62-1PRD" style="display:none;">
 +
 +
 +
 +
 +
 +
  
  
 
<h3>Oncogeniс  Stress</h3>
 
<h3>Oncogeniс  Stress</h3>
<div class="links"> </div>
+
<div class="links"><a href="http://www.ncbi.nlm.nih.gov/pubmed/12748288">PMID: 12748288</a><br /></div>
 
</div>(...)<!--Pop-up for: INF-γ !Pop-up-->
 
</div>(...)<!--Pop-up for: INF-γ !Pop-up-->
 
<div class="1J4WSGPDR-2C3TP3N-BZM" style="display:none;">
 
<div class="1J4WSGPDR-2C3TP3N-BZM" style="display:none;">
 +
 +
 +
 +
 +
 +
  
  
 
<h3>INF-γ</h3>
 
<h3>INF-γ</h3>
<div class="links"> </div>
+
<div class="links"><a href="http://www.ncbi.nlm.nih.gov/pubmed/12011077">PMID: 12011077</a><br /><a href="">INF-γ</a><br /></div>
 
</div>(...)<!--Pop-up for: BMP-2 !Pop-up-->
 
</div>(...)<!--Pop-up for: BMP-2 !Pop-up-->
 
<div class="1NB5JY6MD-1JT7BKF-1R2R" style="display:none;">
 
<div class="1NB5JY6MD-1JT7BKF-1R2R" style="display:none;">
 +
 +
 +
 +
 +
 +
  
  
 
<h3>BMP-2</h3>
 
<h3>BMP-2</h3>
<div class="links"> </div>
+
<div class="links"><a href="http://www.ncbi.nlm.nih.gov/pubmed/16144844">PMID: 16144844</a><br /></div>
 
</div>(...)<!--Pop-up for: Autoimmunity !Pop-up-->
 
</div>(...)<!--Pop-up for: Autoimmunity !Pop-up-->
 
<div class="1NB5LC495-1H6D2WL-1S8H" style="display:none;">
 
<div class="1NB5LC495-1H6D2WL-1S8H" style="display:none;">
 +
 +
 +
 +
 +
 +
  
  
 
<h3>Autoimmunity</h3>
 
<h3>Autoimmunity</h3>
<div class="links"> </div>
+
<div class="links"><a href="http://www.ncbi.nlm.nih.gov/pubmed/16287712">PMID: 16287712</a><br /></div>
 
</div>(...)<!--Pop-up for: Notch !Pop-up-->
 
</div>(...)<!--Pop-up for: Notch !Pop-up-->
 
<div class="1J4WSM985-11LKXT-C7J" style="display:none;">
 
<div class="1J4WSM985-11LKXT-C7J" style="display:none;">
 +
 +
 +
 +
 +
 +
  
  
 
<h3>Notch</h3>
 
<h3>Notch</h3>
<div class="links"> </div>
+
<div class="links"><a href="http://www.ncbi.nlm.nih.gov/pubmed/19592273">PMID: 19592273</a><br /></div>
 
</div>(...)<!--Pop-up for: p73 !Pop-up-->
 
</div>(...)<!--Pop-up for: p73 !Pop-up-->
 
<div class="1J4WPSQ9C-WWBLV4-71G" style="display:none;">
 
<div class="1J4WPSQ9C-WWBLV4-71G" style="display:none;">
 +
 +
 +
 +
 +
 +
  
  
 
<h3>p73</h3>
 
<h3>p73</h3>
<div class="links"> </div>
+
<div class="links"><a href="http://www.ncbi.nlm.nih.gov/pubmed/11193045">PMID: 11193045</a><br /></div>
 
</div>(...)<!--Pop-up for: Deacetylase  HDAC !Pop-up-->
 
</div>(...)<!--Pop-up for: Deacetylase  HDAC !Pop-up-->
 
<div class="1J4WQ6C51-1GW4594-7LP" style="display:none;">
 
<div class="1J4WQ6C51-1GW4594-7LP" style="display:none;">
 +
 +
 +
 +
 +
 +
  
  
 
<h3>Deacetylase  HDAC</h3>
 
<h3>Deacetylase  HDAC</h3>
<div class="links"> </div>
+
<div class="links"><a href="http://www.ncbi.nlm.nih.gov/pubmed/14586402">PMID: 14586402</a><br /></div>
 
</div>(...)<!--Pop-up for: XPG !Pop-up-->
 
</div>(...)<!--Pop-up for: XPG !Pop-up-->
 
<div class="1J4WQYPPZ-28BCRN3-8FS" style="display:none;">
 
<div class="1J4WQYPPZ-28BCRN3-8FS" style="display:none;">
 +
 +
 +
 +
 +
 +
  
  
 
<h3>XPG</h3>
 
<h3>XPG</h3>
<div class="links"> </div>
+
<div class="links"><a href="http://www.ncbi.nlm.nih.gov/pubmed/17599061">PMID: 17599061</a><br /></div>
 
</div>(...)<!--Pop-up for: GM-CSF !Pop-up-->
 
</div>(...)<!--Pop-up for: GM-CSF !Pop-up-->
 
<div class="1NB5JYQSR-21WKLR3-1R31" style="display:none;">
 
<div class="1NB5JYQSR-21WKLR3-1R31" style="display:none;">
 +
 +
 +
 +
 +
 +
  
  
 
<h3>GM-CSF</h3>
 
<h3>GM-CSF</h3>
<div class="links"> </div>
+
<div class="links"><a href="http://www.ncbi.nlm.nih.gov/pubmed/10490824">PMID: 10490824</a><br /></div>
 
</div>(...)<!--Pop-up for: P33 !Pop-up-->
 
</div>(...)<!--Pop-up for: P33 !Pop-up-->
 
<div class="1J4WQ99F5-1MQYTXP-7SW" style="display:none;">
 
<div class="1J4WQ99F5-1MQYTXP-7SW" style="display:none;">
 +
 +
 +
 +
 +
 +
  
  
 
<h3>P33</h3>
 
<h3>P33</h3>
<div class="links"> </div>
+
<div class="links"><a href="http://www.ncbi.nlm.nih.gov/pubmed/11431327">PMID: 11431327</a><br /></div>
 
</div>(...)<!--Pop-up for: RARα !Pop-up-->
 
</div>(...)<!--Pop-up for: RARα !Pop-up-->
 
<div class="1NK00GS0N-19K1V2K-1XP8" style="display:none;">
 
<div class="1NK00GS0N-19K1V2K-1XP8" style="display:none;">
 +
 +
 +
 +
 +
 +
  
  
 
<h3>RARα</h3>
 
<h3>RARα</h3>
<div class="links"> </div>
+
<div class="links"><a href="http://www.ncbi.nlm.nih.gov/pubmed/10872826">PMID: 10872826</a><br /></div>
 
</div>(...)<!--Pop-up for: JNK !Pop-up-->
 
</div>(...)<!--Pop-up for: JNK !Pop-up-->
 
<div class="1J4WPS05W-953WQ6-70L" style="display:none;">
 
<div class="1J4WPS05W-953WQ6-70L" style="display:none;">
 +
 +
 +
 +
 +
 +
  
  
 
<h3>JNK</h3>
 
<h3>JNK</h3>
<div class="links"> </div>
+
<div class="links"><a href="http://www.ncbi.nlm.nih.gov/pubmed/16951155">PMID: 16951155</a><br /></div>
 
</div>(...)<!--Pop-up for: XPC !Pop-up-->
 
</div>(...)<!--Pop-up for: XPC !Pop-up-->
 
<div class="1NB5KPRLV-1PKX397-1S05" style="display:none;">
 
<div class="1NB5KPRLV-1PKX397-1S05" style="display:none;">
 +
 +
 +
 +
 +
 +
  
  
 
<h3>XPC</h3>
 
<h3>XPC</h3>
<div class="links"> </div>
+
<div class="links"><a href="http://www.ncbi.nlm.nih.gov/pubmed/16141330">PMID: 16141330</a><br /></div>
 
</div>(...)<!--Pop-up for: PPARβ !Pop-up-->
 
</div>(...)<!--Pop-up for: PPARβ !Pop-up-->
 
<div class="1NK00J53K-23N2F81-1XRC" style="display:none;">
 
<div class="1NK00J53K-23N2F81-1XRC" style="display:none;">
 +
 +
 +
 +
 +
 +
  
  
 
<h3>PPARβ</h3>
 
<h3>PPARβ</h3>
<div class="links"> </div>
+
<div class="links"><a href="http://www.ncbi.nlm.nih.gov/pubmed/10872826">PMID: 10872826</a><br /></div>
 
</div>(...)<!--Pop-up for: MEKK4 !Pop-up-->
 
</div>(...)<!--Pop-up for: MEKK4 !Pop-up-->
 
<div class="1J4WRQ7TK-HBPS52-9HD" style="display:none;">
 
<div class="1J4WRQ7TK-HBPS52-9HD" style="display:none;">
 +
 +
 +
 +
 +
 +
  
  
 
<h3>MEKK4</h3>
 
<h3>MEKK4</h3>
<div class="links"> </div>
+
<div class="links"><a href="http://www.ncbi.nlm.nih.gov/pubmed/9827804">PMID: 9827804</a><br /></div>
 
</div>(...)<!--Pop-up for: Deacetylase SIRT1 !Pop-up-->
 
</div>(...)<!--Pop-up for: Deacetylase SIRT1 !Pop-up-->
 
<div class="1J4WQ6ZSX-TK6RFP-7MX" style="display:none;">
 
<div class="1J4WQ6ZSX-TK6RFP-7MX" style="display:none;">
 +
 +
 +
 +
 +
 +
  
  
 
<h3>Deacetylase SIRT1</h3>
 
<h3>Deacetylase SIRT1</h3>
<div class="links"> </div>
+
<div class="links"><a href="http://www.ncbi.nlm.nih.gov/pubmed/16012755">PMID: 16012755</a><br /></div>
 
</div>(...)<!--Pop-up for: Pro apoptotic cytokines  !Pop-up-->
 
</div>(...)<!--Pop-up for: Pro apoptotic cytokines  !Pop-up-->
 
<div class="1J4WPQMSC-193N5V2-6ZW" style="display:none;">
 
<div class="1J4WPQMSC-193N5V2-6ZW" style="display:none;">
 +
 +
 +
 +
 +
 +
  
  
 
<h3>Pro apoptotic cytokines </h3>
 
<h3>Pro apoptotic cytokines </h3>
<div class="links"> </div>
+
<div class="links"></div>
 
</div>(...)<!--Pop-up for: ATM !Pop-up-->
 
</div>(...)<!--Pop-up for: ATM !Pop-up-->
 
<div class="1J4WPV9NL-1PXSD8V-72Y" style="display:none;">
 
<div class="1J4WPV9NL-1PXSD8V-72Y" style="display:none;">
 +
 +
 +
 +
 +
 +
  
  
 
<h3>ATM</h3>
 
<h3>ATM</h3>
<div class="links"> </div>
+
<div class="links"><a href="http://www.ncbi.nlm.nih.gov/pubmed/20164679">PMID: 20164679</a><br /></div>
 
</div>(...)<!--Pop-up for: Temporary cell cycle arrest !Pop-up-->
 
</div>(...)<!--Pop-up for: Temporary cell cycle arrest !Pop-up-->
 
<div class="1J4WQ4VRJ-XT7ZDD-7JV" style="display:none;">
 
<div class="1J4WQ4VRJ-XT7ZDD-7JV" style="display:none;">
 +
 +
 +
 +
 +
 +
  
  
 
<h3>Temporary cell cycle arrest</h3>
 
<h3>Temporary cell cycle arrest</h3>
<div class="links"> </div>
+
<div class="links"><a href="http://www.ncbi.nlm.nih.gov/pubmed/10097101">PMID: 10097101</a><br /></div>
 
</div>(...)<!--Pop-up for: INF-γ !Pop-up-->
 
</div>(...)<!--Pop-up for: INF-γ !Pop-up-->
 
<div class="1NB5D8GD0-Y0ZK3D-1PJ3" style="display:none;">
 
<div class="1NB5D8GD0-Y0ZK3D-1PJ3" style="display:none;">
 +
 +
 +
 +
 +
 +
  
  
 
<h3>INF-γ</h3>
 
<h3>INF-γ</h3>
<div class="links"> </div>
+
<div class="links"><a href="http://www.ncbi.nlm.nih.gov/pubmed/12011077">PMID: 12011077</a><br /><a href="">INF-γ</a><br /></div>
 
</div>(...)<!--Pop-up for: Proinflammatory cytokines !Pop-up-->
 
</div>(...)<!--Pop-up for: Proinflammatory cytokines !Pop-up-->
 
<div class="1J4WPLS97-JVQJRM-6Y0" style="display:none;">
 
<div class="1J4WPLS97-JVQJRM-6Y0" style="display:none;">
 +
 +
 +
 +
 +
 +
  
  
 
<h3>Proinflammatory cytokines</h3>
 
<h3>Proinflammatory cytokines</h3>
<div class="links"> </div>
+
<div class="links"></div>
 
</div>(...)<!--Pop-up for: Immunological  Tolerance of T cells !Pop-up-->
 
</div>(...)<!--Pop-up for: Immunological  Tolerance of T cells !Pop-up-->
 
<div class="1J4WSNN7L-7XMJ5L-C9B" style="display:none;">
 
<div class="1J4WSNN7L-7XMJ5L-C9B" style="display:none;">
 +
 +
 +
 +
 +
 +
  
  
 
<h3>Immunological  Tolerance of T cells</h3>
 
<h3>Immunological  Tolerance of T cells</h3>
<div class="links"> </div>
+
<div class="links"><a href="http://www.ncbi.nlm.nih.gov/pubmed/19285438">PMID: 19285438</a><br /></div>
 
</div>(...)<!--Pop-up for: IL-2 !Pop-up-->
 
</div>(...)<!--Pop-up for: IL-2 !Pop-up-->
 
<div class="1NB5D7PK2-28VLNWS-1PHL" style="display:none;">
 
<div class="1NB5D7PK2-28VLNWS-1PHL" style="display:none;">
 +
 +
 +
 +
 +
 +
  
  
 
<h3>IL-2</h3>
 
<h3>IL-2</h3>
<div class="links"> </div>
+
<div class="links"><a href="http://www.ncbi.nlm.nih.gov/pubmed/10490824">PMID: 10490824</a><br /></div>
 
</div>(...)<!--Pop-up for: TGF-β !Pop-up-->
 
</div>(...)<!--Pop-up for: TGF-β !Pop-up-->
 
<div class="1NKRC491D-1S67JNN-2TL" style="display:none;">
 
<div class="1NKRC491D-1S67JNN-2TL" style="display:none;">
 +
 +
 +
 +
 +
 +
  
  
 
<h3>TGF-β</h3>
 
<h3>TGF-β</h3>
<div class="links"> </div>
+
<div class="links"><a href="http://www.ncbi.nlm.nih.gov/pubmed/12456654">PMID: 12456654</a><br /></div>
 
</div>(...)<!--Pop-up for: Differentiation cytokines  !Pop-up-->
 
</div>(...)<!--Pop-up for: Differentiation cytokines  !Pop-up-->
 
<div class="1J4WS1PPW-1100NFG-B7M" style="display:none;">
 
<div class="1J4WS1PPW-1100NFG-B7M" style="display:none;">
 +
 +
 +
 +
 +
 +
  
  
 
<h3>Differentiation cytokines </h3>
 
<h3>Differentiation cytokines </h3>
<div class="links"> </div>
+
<div class="links"></div>
 
</div>(...)<!--Pop-up for: IL-3 !Pop-up-->
 
</div>(...)<!--Pop-up for: IL-3 !Pop-up-->
 
<div class="1NB5JYJN3-1VY2G86-1R2X" style="display:none;">
 
<div class="1NB5JYJN3-1VY2G86-1R2X" style="display:none;">
 +
 +
 +
 +
 +
 +
  
  
 
<h3>IL-3</h3>
 
<h3>IL-3</h3>
<div class="links"> </div>
+
<div class="links"><a href="http://www.ncbi.nlm.nih.gov/pubmed/10490824">PMID: 10490824</a><br /></div>
 
</div>(...)<!--Pop-up for: Demethylation  Of specific CpG  !Pop-up-->
 
</div>(...)<!--Pop-up for: Demethylation  Of specific CpG  !Pop-up-->
 
<div class="1J4WR2YP6-L0T57T-8NH" style="display:none;">
 
<div class="1J4WR2YP6-L0T57T-8NH" style="display:none;">
 +
 +
 +
 +
 +
 +
  
  
 
<h3>Demethylation  Of specific CpG </h3>
 
<h3>Demethylation  Of specific CpG </h3>
<div class="links"> </div>
+
<div class="links"><a href="http://www.ncbi.nlm.nih.gov/pubmed/24104472">PMID: 24104472</a><br /><a href="http://www.ncbi.nlm.nih.gov/pubmed/19377292">PMID: 19377292</a><br /></div>
 
</div>(...)<!--Pop-up for: STAT4 !Pop-up-->
 
</div>(...)<!--Pop-up for: STAT4 !Pop-up-->
 
<div class="1J4WSGBMK-X6JZR1-BYX" style="display:none;">
 
<div class="1J4WSGBMK-X6JZR1-BYX" style="display:none;">
 +
 +
 +
 +
 +
 +
  
  
 
<h3>STAT4</h3>
 
<h3>STAT4</h3>
<div class="links"> </div>
+
<div class="links"><a href="http://www.ncbi.nlm.nih.gov/pubmed/15044949">PMID: 15044949</a><br /></div>
 
</div>(...)<!--Pop-up for: ERα !Pop-up-->
 
</div>(...)<!--Pop-up for: ERα !Pop-up-->
 
<div class="1NK00GK8Y-Z96MRP-1XNZ" style="display:none;">
 
<div class="1NK00GK8Y-Z96MRP-1XNZ" style="display:none;">
 +
 +
 +
 +
 +
 +
  
  
 
<h3>ERα</h3>
 
<h3>ERα</h3>
<div class="links"> </div>
+
<div class="links"><a href="http://www.ncbi.nlm.nih.gov/pubmed/10872826">PMID: 10872826</a><br /></div>
 
</div>(...)<!--Pop-up for: DTX1 !Pop-up-->
 
</div>(...)<!--Pop-up for: DTX1 !Pop-up-->
 
<div class="1J4WSMZGY-14CJ920-C87" style="display:none;">
 
<div class="1J4WSMZGY-14CJ920-C87" style="display:none;">
 +
 +
 +
 +
 +
 +
  
  
 
<h3>DTX1</h3>
 
<h3>DTX1</h3>
<div class="links"> </div>
+
<div class="links"><a href="http://www.ncbi.nlm.nih.gov/pubmed/19592273">PMID: 19592273</a><br /></div>
 
</div>(...)<!--Pop-up for: M-CSF !Pop-up-->
 
</div>(...)<!--Pop-up for: M-CSF !Pop-up-->
 
<div class="1NB5JZ7NY-1WJ1PDQ-1R3F" style="display:none;">
 
<div class="1NB5JZ7NY-1WJ1PDQ-1R3F" style="display:none;">
 +
 +
 +
 +
 +
 +
  
  
 
<h3>M-CSF</h3>
 
<h3>M-CSF</h3>
<div class="links"> </div>
+
<div class="links"><a href="http://www.ncbi.nlm.nih.gov/pubmed/10490824">PMID: 10490824</a><br /></div>
 
</div>(...)<!--Pop-up for: Endoplasmic reticulum stress !Pop-up-->
 
</div>(...)<!--Pop-up for: Endoplasmic reticulum stress !Pop-up-->
 
<div class="1J4WRWHKX-1LFHJ9-B23" style="display:none;">
 
<div class="1J4WRWHKX-1LFHJ9-B23" style="display:none;">
 +
 +
 +
 +
 +
 +
  
  
 
<h3>Endoplasmic reticulum stress</h3>
 
<h3>Endoplasmic reticulum stress</h3>
<div class="links"> </div>
+
<div class="links"><a href="No links!"></a><br /><a href=" ">Endoplasmic reticulum stress</a><br /></div>
 
</div>(...)<!--Pop-up for: P21 !Pop-up-->
 
</div>(...)<!--Pop-up for: P21 !Pop-up-->
 
<div class="1J4WPSBQH-22XCT76-715" style="display:none;">
 
<div class="1J4WPSBQH-22XCT76-715" style="display:none;">
 +
 +
 +
 +
 +
 +
  
  
 
<h3>P21</h3>
 
<h3>P21</h3>
<div class="links"> </div>
+
<div class="links"><a href="http://www.ncbi.nlm.nih.gov/pubmed/12972029">PMID: 12972029</a><br /></div>
 
</div>(...)<!--Pop-up for: MKK7 !Pop-up-->
 
</div>(...)<!--Pop-up for: MKK7 !Pop-up-->
 
<div class="1J4WRP36Q-2DN9LM2-9G4" style="display:none;">
 
<div class="1J4WRP36Q-2DN9LM2-9G4" style="display:none;">
 +
 +
 +
 +
 +
 +
  
  
 
<h3>MKK7</h3>
 
<h3>MKK7</h3>
<div class="links"> </div>
+
<div class="links"><a href="http://www.ncbi.nlm.nih.gov/pubmed/18343408">PMID: 18343408</a><br /></div>
 
</div>(...)<!--Pop-up for: IL-18 !Pop-up-->
 
</div>(...)<!--Pop-up for: IL-18 !Pop-up-->
 
<div class="1NB5D8B5N-Z1VV2S-1PHZ" style="display:none;">
 
<div class="1NB5D8B5N-Z1VV2S-1PHZ" style="display:none;">
 +
 +
 +
 +
 +
 +
  
  
 
<h3>IL-18</h3>
 
<h3>IL-18</h3>
<div class="links"> </div>
+
<div class="links"><a href="http://www.ncbi.nlm.nih.gov/pubmed/11175814">PMID: 11175814</a><br /></div>
 
</div>(...)<!--Pop-up for: Genotoxic  Stress !Pop-up-->
 
</div>(...)<!--Pop-up for: Genotoxic  Stress !Pop-up-->
 
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<h3>Genotoxic  Stress</h3>
 
<h3>Genotoxic  Stress</h3>
<div class="links"> </div>
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<div class="links"><a href="http://www.ncbi.nlm.nih.gov/pubmed/12124778">PMID: 12124778</a><br /></div>
 
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<h3>P38</h3>
 
<h3>P38</h3>
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<div class="links"><a href="http://www.ncbi.nlm.nih.gov/pubmed/16951155">PMID: 16951155</a><br /></div>
 
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<h3>CtIP</h3>
 
<h3>CtIP</h3>
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<h3>DNA repair</h3>
 
<h3>DNA repair</h3>
<div class="links"> </div>
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<div class="links"><a href="http://www.ncbi.nlm.nih.gov/pubmed/12164919">PMID: 12164919</a><br /></div>
 
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<h3>CHOP </h3>
 
<h3>CHOP </h3>
<div class="links"> </div>
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<div class="links"><a href="http://www.ncbi.nlm.nih.gov/pubmed/16131858">PMID: 16131858</a><br /></div>
 
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<h3>Delta12-prostaglandin J2 </h3>
 
<h3>Delta12-prostaglandin J2 </h3>
<div class="links"> </div>
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<div class="links"><a href="http://www.ncbi.nlm.nih.gov/pubmed/9792828">PMID: 9792828</a><br /></div>
 
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<h3>Gadd45α, Gadd45β and Gadd45γ</h3>
 
<h3>Gadd45α, Gadd45β and Gadd45γ</h3>
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<div class="links"><a href="http://www.ncbi.nlm.nih.gov/pubmed/21986581">PMID: 21986581</a><br /></div>
 
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<h3>Cellular  Senescence</h3>
 
<h3>Cellular  Senescence</h3>
<div class="links"> </div>
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<div class="links"><a href="http://www.ncbi.nlm.nih.gov/pubmed/16951155">PMID: 16951155</a><br /></div>
 
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</div>(...)<!--Pop-up for: Stress !Pop-up-->
 
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<h3>Stress</h3>
 
<h3>Stress</h3>
<div class="links"> </div>
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</div>(.//.)<h1>GADD45 pathway</h1>
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<p>Gadd45 genes have been implicated in stress signaling in response to physiological or environmental stressors, which results in cell cycle arrest, DNA repair, cell survival and senescence, or apoptosis. Evidence accumulated implies that Gadd45 proteins function as stress sensors is mediated by a complex interplay of physical interactions with other cellular proteins that are implicated in cell cycle regulation and the response of cells to stress. These include PCNA, p21, cdc2/cyclinB1, and the p38 and JNK stress response kinases. At basal conditions, the expression levels of the Gadd45 family members are relatively low, but they are highly inducible upon a wide plethora of stressful stimuli, both physiological and environmental. </p>
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<p>A decreased ability to cope with stress is one of the hallmarks of aging. Resistance to stress is one of the important determinants of animal survival and longevity. The Gadd45 proteins are implicated in many basic processes shown to be intimately linked to aging and age-related diseases (ARDs), including DNA repair, maintaining genome stability, epigenetic regulation, cell cycle arrest, cellular senescence, apoptosis, cell survival, inflammatory responses and immunity, and embryogenesis.</p>
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<p>Aging is the major risk factor for cancer, and incidence of breast, prostate, colon, lung, stomach, bladder and skin cancer dramatically increases with age. The anti-tumor activity of Gadd45 was shown both in vitro and in vivo studies. For example, ectopic expression of Gadd45 members blocks cell growth by arresting the cells at the G2/M phase and/or induces apoptosis in several human tumor cell lines such as M1 myeloblastic leukemia, H1299 lung carcinoma, HeLa cervical cancer, RKO colon carcinoma, and in non-transformed NIH3T3 mouse embryonic fibroblasts. The silencing of Gadd45 in cancers could be greatly attributed to epigenetic changes that typically occur with advanced age. In particular, promoters of many tumor suppressors were found to be hypermethylated in aging, with subsequent transcriptional gene silencing.</p>
 +
<p>The links between LAGs and Gadd45s make them highly probable candidates for the control of life span. In view of its functions, it seems reasonable that over-expression of Gadd45 might promote longevity, in particular, by increasing the efficiency of DNA repair. Indeed, an opposite situation caused by mutations in the DNA repair genes may lead to hereditary syndromes of premature aging.</p>
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Latest revision as of 09:25, 2 August 2015

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GADD45 pathway

Gadd45 genes have been implicated in stress signaling in response to physiological or environmental stressors, which results in cell cycle arrest, DNA repair, cell survival and senescence, or apoptosis. Evidence accumulated implies that Gadd45 proteins function as stress sensors is mediated by a complex interplay of physical interactions with other cellular proteins that are implicated in cell cycle regulation and the response of cells to stress. These include PCNA, p21, cdc2/cyclinB1, and the p38 and JNK stress response kinases. At basal conditions, the expression levels of the Gadd45 family members are relatively low, but they are highly inducible upon a wide plethora of stressful stimuli, both physiological and environmental.

A decreased ability to cope with stress is one of the hallmarks of aging. Resistance to stress is one of the important determinants of animal survival and longevity. The Gadd45 proteins are implicated in many basic processes shown to be intimately linked to aging and age-related diseases (ARDs), including DNA repair, maintaining genome stability, epigenetic regulation, cell cycle arrest, cellular senescence, apoptosis, cell survival, inflammatory responses and immunity, and embryogenesis.

Aging is the major risk factor for cancer, and incidence of breast, prostate, colon, lung, stomach, bladder and skin cancer dramatically increases with age. The anti-tumor activity of Gadd45 was shown both in vitro and in vivo studies. For example, ectopic expression of Gadd45 members blocks cell growth by arresting the cells at the G2/M phase and/or induces apoptosis in several human tumor cell lines such as M1 myeloblastic leukemia, H1299 lung carcinoma, HeLa cervical cancer, RKO colon carcinoma, and in non-transformed NIH3T3 mouse embryonic fibroblasts. The silencing of Gadd45 in cancers could be greatly attributed to epigenetic changes that typically occur with advanced age. In particular, promoters of many tumor suppressors were found to be hypermethylated in aging, with subsequent transcriptional gene silencing.

The links between LAGs and Gadd45s make them highly probable candidates for the control of life span. In view of its functions, it seems reasonable that over-expression of Gadd45 might promote longevity, in particular, by increasing the efficiency of DNA repair. Indeed, an opposite situation caused by mutations in the DNA repair genes may lead to hereditary syndromes of premature aging.